FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high-throughput luciferase reporter assay to screen 3,756 FDA-approved drugs and bioactive compounds for induction of BMPR2 sign...

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Bibliografiske detaljer
Main Authors: Spiekerkoetter, Edda, Tian, Xuefei, Cai, Jie, Hopper, Rachel K., Sudheendra, Deepti, Li, Caiyun G., El-Bizri, Nesrine, Sawada, Hirofumi, Haghighat, Roxanna, Chan, Roshelle, Haghighat, Leila, de Jesus Perez, Vinicio, Wang, Lingli, Reddy, Sushma, Zhao, Mingming, Bernstein, Daniel, Solow-Cordero, David E., Beachy, Philip A., Wandless, Thomas J., ten Dijke, Peter, Rabinovitch, Marlene
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726153/
https://ncbi.nlm.nih.gov/pubmed/23867624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65592
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