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Increased Susceptibility to Methotrexate-Induced Toxicity in Nonalcoholic Steatohepatitis

Hepatic drug metabolizing enzymes and transporters play a crucial role in determining the fate of drugs, and alterations in liver function can place individuals at greater risk for adverse drug reactions (ADRs). We have shown that nonalcoholic steatohepatitis (NASH) leads to changes in the expressio...

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Foilsithe in:Toxicol Sci
Main Authors: Hardwick, Rhiannon N., Clarke, John D., Lake, April D., Canet, Mark J., Anumol, Tarun, Street, Stephanie M., Merrell, Matthew D., Goedken, Michael J., Snyder, Shane A., Cherrington, Nathan J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334808/
https://ncbi.nlm.nih.gov/pubmed/25080921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu156
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