Increased Susceptibility to Methotrexate-Induced Toxicity in Nonalcoholic Steatohepatitis

Hepatic drug metabolizing enzymes and transporters play a crucial role in determining the fate of drugs, and alterations in liver function can place individuals at greater risk for adverse drug reactions (ADRs). We have shown that nonalcoholic steatohepatitis (NASH) leads to changes in the expressio...

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Gepubliceerd in:Toxicol Sci
Hoofdauteurs: Hardwick, Rhiannon N., Clarke, John D., Lake, April D., Canet, Mark J., Anumol, Tarun, Street, Stephanie M., Merrell, Matthew D., Goedken, Michael J., Snyder, Shane A., Cherrington, Nathan J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2014
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334808/
https://ncbi.nlm.nih.gov/pubmed/25080921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu156
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