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Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis
Ezetimibe (EZE) lowers serum lipid levels by blocking cholesterol uptake in the intestine. Disposition of EZE and its pharmacologically active glucuronide metabolite (EZE-GLUC) to the intestine is dependent on hepatobiliary efflux. Previous studies suggested that hepatic transporter expression and f...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286272/ https://ncbi.nlm.nih.gov/pubmed/22112382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.041095 |
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