Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis

Ezetimibe (EZE) lowers serum lipid levels by blocking cholesterol uptake in the intestine. Disposition of EZE and its pharmacologically active glucuronide metabolite (EZE-GLUC) to the intestine is dependent on hepatobiliary efflux. Previous studies suggested that hepatic transporter expression and f...

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Bibliographic Details
Main Authors: Hardwick, Rhiannon N., Fisher, Craig D., Street, Stephanie M., Canet, Mark J., Cherrington, Nathan J.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286272/
https://ncbi.nlm.nih.gov/pubmed/22112382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.041095
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