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Mechanistic Basis of Altered Morphine Disposition in Nonalcoholic Steatohepatitis
Morphine is metabolized in humans to morphine-3-glucuronide (M3G) and the pharmacologically active morphine-6-glucuronide (M6G). The hepatobiliary disposition of both metabolites relies upon multidrug resistance-associated proteins Mrp3 and Mrp2, located on the sinusoidal and canalicular membrane, r...
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| Publicado en: | J Pharmacol Exp Ther |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4352592/ https://ncbi.nlm.nih.gov/pubmed/25512370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.220764 |
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