Mechanistic Basis of Altered Morphine Disposition in Nonalcoholic Steatohepatitis

Morphine is metabolized in humans to morphine-3-glucuronide (M3G) and the pharmacologically active morphine-6-glucuronide (M6G). The hepatobiliary disposition of both metabolites relies upon multidrug resistance-associated proteins Mrp3 and Mrp2, located on the sinusoidal and canalicular membrane, r...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Dzierlenga, Anika L., Clarke, John D., Hargraves, Tiffanie L., Ainslie, Garrett R., Vanderah, Todd W., Paine, Mary F., Cherrington, Nathan J.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2015
Subjects:
Metabolism, Transport, and Pharmacogenomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352592/
https://ncbi.nlm.nih.gov/pubmed/25512370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.220764
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