Mechanistic Basis of Altered Morphine Disposition in Nonalcoholic Steatohepatitis

Morphine is metabolized in humans to morphine-3-glucuronide (M3G) and the pharmacologically active morphine-6-glucuronide (M6G). The hepatobiliary disposition of both metabolites relies upon multidrug resistance-associated proteins Mrp3 and Mrp2, located on the sinusoidal and canalicular membrane, r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pharmacol Exp Ther
Prif Awduron: Dzierlenga, Anika L., Clarke, John D., Hargraves, Tiffanie L., Ainslie, Garrett R., Vanderah, Todd W., Paine, Mary F., Cherrington, Nathan J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2015
Pynciau:
Metabolism, Transport, and Pharmacogenomics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352592/
https://ncbi.nlm.nih.gov/pubmed/25512370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.220764
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg