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Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis

Ezetimibe (EZE) lowers serum lipid levels by blocking cholesterol uptake in the intestine. Disposition of EZE and its pharmacologically active glucuronide metabolite (EZE-GLUC) to the intestine is dependent on hepatobiliary efflux. Previous studies suggested that hepatic transporter expression and f...

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Detaylı Bibliyografya
Asıl Yazarlar: Hardwick, Rhiannon N., Fisher, Craig D., Street, Stephanie M., Canet, Mark J., Cherrington, Nathan J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286272/
https://ncbi.nlm.nih.gov/pubmed/22112382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.041095
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