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Experimental Nonalcoholic Steatohepatitis Increases Exposure to Simvastatin Hydroxy Acid by Decreasing Hepatic Organic Anion Transporting Polypeptide Expression

Simvastatin (SIM)-induced myopathy is a dose-dependent adverse drug reaction (ADR) that has been reported to occur in 18.2% of patients receiving a 40- to 80-mg dose. The pharmacokinetics of SIM hydroxy acid (SIMA), the bioactive form of SIM, and the occurrence of SIM-induced myopathy are linked to...

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Main Authors: Clarke, John D., Hardwick, Rhiannon N., Lake, April D., Canet, Mark J., Cherrington, Nathan J.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935144/
https://ncbi.nlm.nih.gov/pubmed/24403518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.211284
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