Increased Susceptibility to Methotrexate-Induced Toxicity in Nonalcoholic Steatohepatitis

Hepatic drug metabolizing enzymes and transporters play a crucial role in determining the fate of drugs, and alterations in liver function can place individuals at greater risk for adverse drug reactions (ADRs). We have shown that nonalcoholic steatohepatitis (NASH) leads to changes in the expressio...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Hardwick, Rhiannon N., Clarke, John D., Lake, April D., Canet, Mark J., Anumol, Tarun, Street, Stephanie M., Merrell, Matthew D., Goedken, Michael J., Snyder, Shane A., Cherrington, Nathan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334808/
https://ncbi.nlm.nih.gov/pubmed/25080921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu156
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