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Increased Susceptibility to Methotrexate-Induced Toxicity in Nonalcoholic Steatohepatitis

Hepatic drug metabolizing enzymes and transporters play a crucial role in determining the fate of drugs, and alterations in liver function can place individuals at greater risk for adverse drug reactions (ADRs). We have shown that nonalcoholic steatohepatitis (NASH) leads to changes in the expressio...

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Bibliografiske detaljer
Udgivet i:Toxicol Sci
Main Authors: Hardwick, Rhiannon N., Clarke, John D., Lake, April D., Canet, Mark J., Anumol, Tarun, Street, Stephanie M., Merrell, Matthew D., Goedken, Michael J., Snyder, Shane A., Cherrington, Nathan J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334808/
https://ncbi.nlm.nih.gov/pubmed/25080921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu156
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