Increased Susceptibility to Methotrexate-Induced Toxicity in Nonalcoholic Steatohepatitis

Hepatic drug metabolizing enzymes and transporters play a crucial role in determining the fate of drugs, and alterations in liver function can place individuals at greater risk for adverse drug reactions (ADRs). We have shown that nonalcoholic steatohepatitis (NASH) leads to changes in the expressio...

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發表在:Toxicol Sci
Main Authors: Hardwick, Rhiannon N., Clarke, John D., Lake, April D., Canet, Mark J., Anumol, Tarun, Street, Stephanie M., Merrell, Matthew D., Goedken, Michael J., Snyder, Shane A., Cherrington, Nathan J.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2014
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334808/
https://ncbi.nlm.nih.gov/pubmed/25080921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu156
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