The Selective Loss of the Type 2 Iodothyronine Deiodinase in Mouse Thyrotrophs Increases Basal TSH but Blunts the Thyrotropin Response to Hypothyroidism

The type 2 iodothyronine deiodinase (D2) is essential for feedback regulation of TSH by T(4). We genetically inactivated in vivo D2 in thyrotrophs using a mouse model of Cga-driven cre recombinase. Pituitary D2 activity was reduced 90% in the Cga-cre D2 knockout (KO) mice compared with control Dio2(...

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Bibliographic Details
Published in:Endocrinology
Main Authors: Luongo, Cristina, Martin, Cecilia, Vella, Kristen, Marsili, Alessandro, Ambrosio, Raffaele, Dentice, Monica, Harney, John W., Salvatore, Domenico, Zavacki, Ann Marie, Larsen, P. Reed
Format: Artigo
Language:Inglês
Published: Endocrine Society 2015
Subjects:
Thyroid-TRH-TSH
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298316/
https://ncbi.nlm.nih.gov/pubmed/25456070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1698
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