Φορτώνει......
The Selective Loss of the Type 2 Iodothyronine Deiodinase in Mouse Thyrotrophs Increases Basal TSH but Blunts the Thyrotropin Response to Hypothyroidism
The type 2 iodothyronine deiodinase (D2) is essential for feedback regulation of TSH by T(4). We genetically inactivated in vivo D2 in thyrotrophs using a mouse model of Cga-driven cre recombinase. Pituitary D2 activity was reduced 90% in the Cga-cre D2 knockout (KO) mice compared with control Dio2(...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Endocrinology |
|---|---|
| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Endocrine Society
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4298316/ https://ncbi.nlm.nih.gov/pubmed/25456070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1698 |
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