The Selective Loss of the Type 2 Iodothyronine Deiodinase in Mouse Thyrotrophs Increases Basal TSH but Blunts the Thyrotropin Response to Hypothyroidism

The type 2 iodothyronine deiodinase (D2) is essential for feedback regulation of TSH by T(4). We genetically inactivated in vivo D2 in thyrotrophs using a mouse model of Cga-driven cre recombinase. Pituitary D2 activity was reduced 90% in the Cga-cre D2 knockout (KO) mice compared with control Dio2(...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Endocrinology
Hlavní autoři: Luongo, Cristina, Martin, Cecilia, Vella, Kristen, Marsili, Alessandro, Ambrosio, Raffaele, Dentice, Monica, Harney, John W., Salvatore, Domenico, Zavacki, Ann Marie, Larsen, P. Reed
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2015
Témata:
Thyroid-TRH-TSH
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298316/
https://ncbi.nlm.nih.gov/pubmed/25456070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1698
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky