ロード中...
The Selective Loss of the Type 2 Iodothyronine Deiodinase in Mouse Thyrotrophs Increases Basal TSH but Blunts the Thyrotropin Response to Hypothyroidism
The type 2 iodothyronine deiodinase (D2) is essential for feedback regulation of TSH by T(4). We genetically inactivated in vivo D2 in thyrotrophs using a mouse model of Cga-driven cre recombinase. Pituitary D2 activity was reduced 90% in the Cga-cre D2 knockout (KO) mice compared with control Dio2(...
保存先:
| 出版年: | Endocrinology |
|---|---|
| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Endocrine Society
2015
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4298316/ https://ncbi.nlm.nih.gov/pubmed/25456070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1698 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|