In Vivo Phenotypic Screening for Treating Chronic Neuropathic Pain: Modification of C2-Arylethynyl Group of Conformationally Constrained A(3) Adenosine Receptor Agonists

[Image: see text] (N)-Methanocarba adenosine 5′-methyluronamides containing 2-arylethynyl groups were synthesized as A(3) adenosine receptor (AR) agonists and screened in vivo (po) for reduction of neuropathic pain. A small N(6)-methyl group maintained binding affinity, with human > mouse A(3)AR...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Tosh, Dilip K., Finley, Amanda, Paoletta, Silvia, Moss, Steven M., Gao, Zhan-Guo, Gizewski, Elizabeth T., Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266358/
https://ncbi.nlm.nih.gov/pubmed/25422861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501021n
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