(11)C-CUMI-101, a PET Radioligand, Behaves as a Serotonin 1A Receptor Antagonist and Also Binds to α(1) Adrenoceptors in Brain

The PET radioligand (11)C-CUMI-101 was previously suggested as a putative agonist radioligand for the serotonin 1A (5-hydroxytryptamine 1A [5-HT(1A)]) receptor in recombinant cells expressing human 5-HT(1A) receptor. However, a recent study showed that CUMI-101 behaved as a potent 5-HT(1A) receptor...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Shrestha, Stal Saurav, Liow, Jeih-San, Lu, Shuiyu, Jenko, Kimberly, Gladding, Robert L., Svenningsson, Per, Morse, Cheryl L., Zoghbi, Sami S., Pike, Victor W., Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247002/
https://ncbi.nlm.nih.gov/pubmed/24385311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.113.125831
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