Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase

[Image: see text] A series of antiviral basic quinolinonyl diketo acid derivatives were developed as inhibitors of HIV-1 IN. Compounds 12d,f,i inhibited HIV-1 IN with IC(50) values below 100 nM for strand transfer and showed a 2 order of magnitude selectivity over 3′-processing. These strand transfe...

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Main Authors: Costi, Roberta, Métifiot, Mathieu, Chung, Suhman, Cuzzucoli Crucitti, Giuliana, Maddali, Kasthuraiah, Pescatori, Luca, Messore, Antonella, Madia, Valentina Noemi, Pupo, Giovanni, Scipione, Luigi, Tortorella, Silvano, Di Leva, Francesco Saverio, Cosconati, Sandro, Marinelli, Luciana, Novellino, Ettore, Le Grice, Stuart F. J., Corona, Angela, Pommier, Yves, Marchand, Christophe, Di Santo, Roberto
格式: Artigo
語言:Inglês
出版: American Chemical Society 2014
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203401/
https://ncbi.nlm.nih.gov/pubmed/24684270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5001503
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