N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase

Bifunctional quinolinonyl DKA derivatives were first described as nonselective inhibitors of 3′-processing (3′-P) and strand transfer (ST) functions of HIV-1 integrase (IN), while 7-aminosubstituted quinolinonyl derivatives were proven IN strand transfer inhibitors (INSTIs) that also displayed activ...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Med Chem
Κύριοι συγγραφείς: Pescatori, Luca, Métifiot, Mathieu, Chung, Suhman, Masoaka, Takashi, Crucitti, Giuliana Cuzzucoli, Messore, Antonella, Pupo, Giovanni, Madia, Valentina Noemi, Saccoliti, Francesco, Scipione, Luigi, Tortorella, Silvano, Di Leva, Francesco Saverio, Cosconati, Sandro, Marinelli, Luciana, Novellino, Ettore, Le Grice, Stuart F. J., Pommier, Yves, Marchand, Christophe, Costi, Roberta, Di Santo, Roberto
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2015
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320704/
https://ncbi.nlm.nih.gov/pubmed/25961960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00159
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