N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase

Bifunctional quinolinonyl DKA derivatives were first described as nonselective inhibitors of 3′-processing (3′-P) and strand transfer (ST) functions of HIV-1 integrase (IN), while 7-aminosubstituted quinolinonyl derivatives were proven IN strand transfer inhibitors (INSTIs) that also displayed activ...

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Publicado no:J Med Chem
Main Authors: Pescatori, Luca, Métifiot, Mathieu, Chung, Suhman, Masoaka, Takashi, Crucitti, Giuliana Cuzzucoli, Messore, Antonella, Pupo, Giovanni, Madia, Valentina Noemi, Saccoliti, Francesco, Scipione, Luigi, Tortorella, Silvano, Di Leva, Francesco Saverio, Cosconati, Sandro, Marinelli, Luciana, Novellino, Ettore, Le Grice, Stuart F. J., Pommier, Yves, Marchand, Christophe, Costi, Roberta, Di Santo, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320704/
https://ncbi.nlm.nih.gov/pubmed/25961960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00159
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