Structure–Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

The development of HIV-1 dual inhibitors is a highly innovative approach aimed at reducing drug toxic side effects as well as therapeutic costs. HIV-1 integrase (IN) and reverse transcriptase-associated ribonuclease H (RNase H) are both selective targets for HIV-1 chemotherapy, and the identificatio...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Crucitti, Giuliana Cuzzucoli, Métifiot, Mathieu, Pescatori, Luca, Messore, Antonella, Madia, Valentina Noemi, Pupo, Giovanni, Saccoliti, Francesco, Scipione, Luigi, Tortorella, Silvano, Esposito, Francesca, Corona, Angela, Cadeddu, Marta, Marchand, Christophe, Pommier, Yves, Tramontano, Enzo, Costi, Roberta, Di Santo, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745740/
https://ncbi.nlm.nih.gov/pubmed/25629256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501799k
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