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6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic Acids as Dual Inhibitors of Recombinant HIV-1 Integrase and Ribonuclease H, Synthesized by a Parallel Synthesis Approach

The increasing efficiency of HAART has helped to transform HIV/AIDS into a chronic disease. Still, resistance and drug–drug interactions warrant the development of new anti-HIV agents. We previously discovered hit 6, active against HIV-1 replication and targeting RNase H in vitro. Because of its dik...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Costi, Roberta, Métifiot, Mathieu, Esposito, Francesca, Crucitti, Giuliana Cuzzucoli, Pescator, Luca, Messore, Antonella, Scipione, Luigi, Tortorella, Silvano, Zinzula, Luca, Novellino, Ettore, Pommier, Yves, Tramontano, Enzo, Marchand, Christophe, Di Santo, Roberto
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581279/
https://ncbi.nlm.nih.gov/pubmed/24124919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401040b
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