Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

[Image: see text] Novel anti-HIV agents are still needed to overcome resistance issues, in particular inhibitors acting against novel viral targets. The ribonuclease H (RNase H) function of the reverse transcriptase (RT) represents a validated and promising target, and no inhibitor has reached the c...

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Publicado no:J Med Chem
Main Authors: Messore, Antonella, Corona, Angela, Madia, Valentina Noemi, Saccoliti, Francesco, Tudino, Valeria, De Leo, Alessandro, Ialongo, Davide, Scipione, Luigi, De Vita, Daniela, Amendola, Giorgio, Novellino, Ettore, Cosconati, Sandro, Métifiot, Mathieu, Andreola, Marie-Line, Esposito, Francesca, Grandi, Nicole, Tramontano, Enzo, Costi, Roberta, Di Santo, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279492/
https://ncbi.nlm.nih.gov/pubmed/34106711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00535
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