Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities

[Image: see text] Novel quinolinonyl diketo acids were designed to obtain integrase (IN) inhibitors selectively active against the strand transfer (ST) step of the HIV integration process. Those new compounds are characterized by a single aryl diketo acid (DKA) chain in comparison to 4, a bifunction...

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Main Authors: Di Santo, Roberto, Costi, Roberta, Roux, Alessandra, Miele, Gaetano, Crucitti, Giuliana Cuzzucoli, Iacovo, Alberto, Rosi, Federica, Lavecchia, Antonio, Marinelli, Luciana, Di Giovanni, Carmen, Novellino, Ettore, Palmisano, Lucia, Andreotti, Mauro, Amici, Roberta, Galluzzo, Clementina Maria, Nencioni, Lucia, Palamara, Anna Teresa, Pommier, Yves, Marchand, Christophe
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2008
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646871/
https://ncbi.nlm.nih.gov/pubmed/18646746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8001422
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