Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities

[Image: see text] Novel quinolinonyl diketo acids were designed to obtain integrase (IN) inhibitors selectively active against the strand transfer (ST) step of the HIV integration process. Those new compounds are characterized by a single aryl diketo acid (DKA) chain in comparison to 4, a bifunction...

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Detalhes bibliográficos
Main Authors: Di Santo, Roberto, Costi, Roberta, Roux, Alessandra, Miele, Gaetano, Crucitti, Giuliana Cuzzucoli, Iacovo, Alberto, Rosi, Federica, Lavecchia, Antonio, Marinelli, Luciana, Di Giovanni, Carmen, Novellino, Ettore, Palmisano, Lucia, Andreotti, Mauro, Amici, Roberta, Galluzzo, Clementina Maria, Nencioni, Lucia, Palamara, Anna Teresa, Pommier, Yves, Marchand, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2008
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646871/
https://ncbi.nlm.nih.gov/pubmed/18646746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8001422
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