Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities

[Image: see text] Novel quinolinonyl diketo acids were designed to obtain integrase (IN) inhibitors selectively active against the strand transfer (ST) step of the HIV integration process. Those new compounds are characterized by a single aryl diketo acid (DKA) chain in comparison to 4, a bifunction...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Di Santo, Roberto, Costi, Roberta, Roux, Alessandra, Miele, Gaetano, Crucitti, Giuliana Cuzzucoli, Iacovo, Alberto, Rosi, Federica, Lavecchia, Antonio, Marinelli, Luciana, Di Giovanni, Carmen, Novellino, Ettore, Palmisano, Lucia, Andreotti, Mauro, Amici, Roberta, Galluzzo, Clementina Maria, Nencioni, Lucia, Palamara, Anna Teresa, Pommier, Yves, Marchand, Christophe
التنسيق: Artigo
اللغة:Inglês
منشور في: American Chemical Society 2008
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646871/
https://ncbi.nlm.nih.gov/pubmed/18646746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8001422
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