Novel Bifunctional Quinolonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, Biological Activities and Mechanism of Action

The virally encoded integrase protein is an essential enzyme in the life cycle of the HIV-1 virus and represents an attractive and validated target in the development of therapeutics against HIV infection. Drugs that selectively inhibit this enzyme, when used in combination with inhibitors of revers...

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Detalhes bibliográficos
Main Authors: Di Santo, Roberto, Costi, Roberta, Roux, Alessandra, Artico, Marino, Lavecchia, Antonio, Marinelli, Luciana, Novellino, Ettore, Palmisano, Lucia, Andreotti, Mauro, Amici, Roberta, Galluzzo, Clementina Maria, Nencioni, Lucia, Palamara, Anna Teresa, Pommier, Yves, Marchand, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602756/
https://ncbi.nlm.nih.gov/pubmed/16539381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0511583
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