Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase

[Image: see text] Due to the biological liability of diketo acid (DKA) chain, we transferred this element of our previously reported anti-HIV-1 pyrrolyl derivatives to a non-DKA scaffold, obtaining a series of pyrrolyl–pyrazole carboxylic acids as new RNase H inhibitors. Among the newly synthesized...

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הוצא לאור ב:ACS Med Chem Lett
Main Authors: Messore, Antonella, Corona, Angela, Madia, Valentina Noemi, Saccoliti, Francesco, Tudino, Valeria, De Leo, Alessandro, Scipione, Luigi, De Vita, Daniela, Amendola, Giorgio, Di Maro, Salvatore, Novellino, Ettore, Cosconati, Sandro, Métifiot, Mathieu, Andreola, Marie-Line, Valenti, Piera, Esposito, Francesca, Grandi, Nicole, Tramontano, Enzo, Costi, Roberta, Di Santo, Roberto
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2020
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236236/
https://ncbi.nlm.nih.gov/pubmed/32435387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00617
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