Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

HIV-1 reverse transcriptase (RT)-associated RNase H activity is an essential function in viral genome retrotranscription. RNase H is a promising drug target for which no inhibitor is available for therapy. Diketo acid (DKA) derivatives are active site Mg(2+)-binding inhibitors of both HIV-1 RNase H...

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Detalhes bibliográficos
Main Authors: Corona, Angela, Di Leva, Francesco Saverio, Thierry, Sylvain, Pescatori, Luca, Cuzzucoli Crucitti, Giuliana, Subra, Frederic, Delelis, Olivier, Esposito, Francesca, Rigogliuso, Giuseppe, Costi, Roberta, Cosconati, Sandro, Novellino, Ettore, Di Santo, Roberto, Tramontano, Enzo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187941/
https://ncbi.nlm.nih.gov/pubmed/25092689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03605-14
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