Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors

[Image: see text] Recent studies have revealed that several histone deacetylase (HDAC) inhibitors, which are used to study/treat brain diseases, show low blood-brain barrier (BBB) penetration. In addition to low HDAC potency and selectivity observed, poor brain penetrance may account for the high do...

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Bibliographische Detailangaben
Hauptverfasser: Seo, Young Jun, Kang, Yeona, Muench, Lisa, Reid, Alicia, Caesar, Shannon, Jean, Logan, Wagner, Florence, Holson, Edward, Haggarty, Stephen J., Weiss, Philipp, King, Payton, Carter, Pauline, Volkow, Nora D., Fowler, Joanna S., Hooker, Jacob M., Kim, Sung Won
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102966/
https://ncbi.nlm.nih.gov/pubmed/24780082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500021p
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