Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors

[Image: see text] Recent studies have revealed that several histone deacetylase (HDAC) inhibitors, which are used to study/treat brain diseases, show low blood-brain barrier (BBB) penetration. In addition to low HDAC potency and selectivity observed, poor brain penetrance may account for the high do...

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Main Authors: Seo, Young Jun, Kang, Yeona, Muench, Lisa, Reid, Alicia, Caesar, Shannon, Jean, Logan, Wagner, Florence, Holson, Edward, Haggarty, Stephen J., Weiss, Philipp, King, Payton, Carter, Pauline, Volkow, Nora D., Fowler, Joanna S., Hooker, Jacob M., Kim, Sung Won
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102966/
https://ncbi.nlm.nih.gov/pubmed/24780082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500021p
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