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Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors
[Image: see text] Recent studies have revealed that several histone deacetylase (HDAC) inhibitors, which are used to study/treat brain diseases, show low blood-brain barrier (BBB) penetration. In addition to low HDAC potency and selectivity observed, poor brain penetrance may account for the high do...
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Main Authors: | , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Chemical
Society
2014
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4102966/ https://ncbi.nlm.nih.gov/pubmed/24780082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500021p |
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