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Histone Deacetylase Inhibitor MS-275 Exhibits Poor Brain Penetration: Pharmacokinetic Studies of [(11)C]MS-275 using Positron Emission Tomography
[Image: see text] MS-275 (entinostat) is a histone deacetylase (HDAC) inhibitor currently in clinical trials for the treatment of several types of cancer. Recent reports have noted that MS-275 can cross the blood−brain barrier (BBB) and cause region-specific changes in rodent brain histone acetylati...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical Society
2009
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2908422/ https://ncbi.nlm.nih.gov/pubmed/20657706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn9000268 |
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