Radionuclide Labeling and Evaluation of Candidate Radioligands for PET Imaging of Histone Deacetylase in the Brain

Histone deacetylases (HDACs) regulate gene expression by inducing conformational changes in chromatin. Ever since the discovery of a naturally occurring HDAC inhibitor, trichostatin A (TSA) stimulated the recent development of suberoylanilide (SAHA, Zolinza(®)), HDAC has become an important molecula...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Seo, Young Jun, Muench, Lisa, Reid, Alicia, Chen, Jinzhu, Kang, Yeona, Hooker, Jacob M., Volkow, Nora D., Fowler, Joanna S., Kim, Sung Won
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007514/
https://ncbi.nlm.nih.gov/pubmed/24210501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.10.038
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