Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

[Image: see text] Phosphoinositide 3-kinase α (PI3Kα) is a critical regulator of cell growth and transformation, and its signaling pathway is the most commonly mutated pathway in human cancers. The mammalian target of rapamycin (mTOR), a class IV PI3K protein kinase, is also a central regulator of c...

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Главные авторы: Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Luengo, Juan I., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn S., Carson, Jeffrey D., Diamond, Melody A., Elkins, Patricia A., Gardiner, Christine M., Garver, Eric, Gilbert, Seth A., Gontarek, Richard R., Jackson, Jeffrey R., Kershner, Kevin L., Luo, Lusong, Raha, Kaushik, Sherk, Christian S., Sung, Chiu-Mei, Sutton, David, Tummino, Peter J., Wegrzyn, Ronald J., Auger, Kurt R., Dhanak, Dashyant
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2010
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007793/
https://ncbi.nlm.nih.gov/pubmed/24900173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml900028r
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