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Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

BACKGROUND: Myelosuppression has been observed with several multikinase angiogenesis inhibitors in clinical studies, although the frequency and severity varies among the different agents. Inhibitors targeting vascular endothelial growth factor receptor (VEGFR) often inhibit other kinases, which may...

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Detalhes bibliográficos
Main Authors: Kumar, R, Crouthamel, M-C, Rominger, D H, Gontarek, R R, Tummino, P J, Levin, R A, King, A G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768111/
https://ncbi.nlm.nih.gov/pubmed/19844230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605366
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