Pharmacological characterization of SB-710411 (Cpa-c[D-Cys-Pal-D-Trp-Lys-Val-Cys]-Cpa-amide), a novel peptidic urotensin-II receptor antagonist

1. Human urotensin-II (hU-II), a cyclic undecapeptide, is amongst the most potent mammalian vasoconstrictors identified, suggesting that hU-II and its G-protein-coupled receptor (UT) may regulate cardiovascular homeostasis. Such a hypothesis would benefit greatly from the development of selective UT...

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Main Authors: Behm, David J, Herold, Christopher L, Ohlstein, Eliot H, Knight, Steven D, Dhanak, Dashyant, Douglas, Stephen A
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573512/
https://ncbi.nlm.nih.gov/pubmed/12359626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704887
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