Nonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375

1. SB-706375 potently inhibited [(125)I]hU-II binding to both mammalian recombinant and ‘native' UT receptors (K(i) 4.7±1.5 to 20.7±3.6 nM at rodent, feline and primate recombinant UT receptors and K(i) 5.4±0.4 nM at the endogenous UT receptor in SJRH30 cells). 2. Prior exposure to SB-706375 (1...

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Main Authors: Douglas, Stephen A, Behm, David J, Aiyar, Nambi V, Naselsky, Diane, Disa, Jyoti, Brooks, David P, Ohlstein, Eliot H, Gleason, John G, Sarau, Henry M, Foley, James J, Buckley, Peter T, Schmidt, Dulcie B, Wixted, William E, Widdowson, Katherine, Riley, Graham, Jin, Jian, Gallagher, Timothy F, Schmidt, Stanley J, Ridgers, Lance, Christmann, Lisa T, Keenan, Richard M, Knight, Steven D, Dhanak, Dashyant
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576177/
https://ncbi.nlm.nih.gov/pubmed/15852036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706229
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