Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

There is great interest in the design and development of highly thermostable and immunogenic protein subunit vaccines for biodefense. In this study, we used two orthogonal and complementary computational protein design approaches to generate a series of single-point mutants of RiVax, an attenuated r...

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Detalhes bibliográficos
Main Authors: Thomas, Justin C., O’Hara, Joanne M., Hu, Lei, Gao, Fei P., Joshi, Sangeeta B., Volkin, David B., Brey, Robert N., Fang, Jianwen, Karanicolas, John, Mantis, Nicholas J., Middaugh, C. Russell
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903890/
https://ncbi.nlm.nih.gov/pubmed/23563512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.22998
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