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Neutralizing Monoclonal Antibodies against Ricin’s Enzymatic Subunit Interfere with Protein Disulfide Isomerase-Mediated Reduction of Ricin Holotoxin In Vitro

The penultimate event in the intoxication of mammalian cells by ricin toxin is the reduction, in the endoplasmic reticulum (ER), of the intermolecular disulfide bond that links ricin’s enzymatic (RTA) and binding (RTB) subunits. In this report we adapted an in vitro protein disulfide isomerase (PDI)...

詳細記述

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書誌詳細
主要な著者: O’Hara, Joanne M., Mantis, Nicholas J.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753220/
https://ncbi.nlm.nih.gov/pubmed/23774033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2013.06.004
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