Загрузка...

Neutralizing Monoclonal Antibodies against Ricin’s Enzymatic Subunit Interfere with Protein Disulfide Isomerase-Mediated Reduction of Ricin Holotoxin In Vitro

The penultimate event in the intoxication of mammalian cells by ricin toxin is the reduction, in the endoplasmic reticulum (ER), of the intermolecular disulfide bond that links ricin’s enzymatic (RTA) and binding (RTB) subunits. In this report we adapted an in vitro protein disulfide isomerase (PDI)...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: O’Hara, Joanne M., Mantis, Nicholas J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753220/
https://ncbi.nlm.nih.gov/pubmed/23774033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2013.06.004
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!