Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

There is great interest in the design and development of highly thermostable and immunogenic protein subunit vaccines for biodefense. In this study, we used two orthogonal and complementary computational protein design approaches to generate a series of single-point mutants of RiVax, an attenuated r...

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Autori principali: Thomas, Justin C., O’Hara, Joanne M., Hu, Lei, Gao, Fei P., Joshi, Sangeeta B., Volkin, David B., Brey, Robert N., Fang, Jianwen, Karanicolas, John, Mantis, Nicholas J., Middaugh, C. Russell
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903890/
https://ncbi.nlm.nih.gov/pubmed/23563512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.22998
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