Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012

This Letter describes the continued optimization of an MLPCN probe molecule M(1) antagonist (ML012) through an iterative parallel synthesis approach. After several rounds of modifications of the parent compound, we arrived at a new azetidine scaffold that displayed improved potency while maintaining...

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Detalhes bibliográficos
Main Authors: Melancon, Bruce J., Utley, Thomas J., Sevel, Christian, Mattmann, Margrith E., Cheung, Yiu-Yin, Bridges, Thomas M., Morrison, Ryan D., Sheffler, Douglas J., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883446/
https://ncbi.nlm.nih.gov/pubmed/22749871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.06.018
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