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The Thyrotropin Receptor Hinge Region as a Surrogate Ligand: Identification of Loci Contributing to the Coupling of Thyrotropin Binding and Receptor Activation

The TSH receptor (TSHR) hinge region, the least well understood component, bridges the leucine-rich repeat and transmembrane domains. We report data on clusters of hinge charged residues the mutation of which to Ala is compatible with cell surface expression and normal, or near normal, TSH binding a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Chun-Rong, Salazar, Larry M., McLachlan, Sandra M., Rapoport, Basil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512008/
https://ncbi.nlm.nih.gov/pubmed/23002040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1376
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