Probing Structural Variability at the N Terminus of the TSH Receptor with a Murine Monoclonal Antibody That Distinguishes between Two Receptor Conformational Forms

Despite elucidation of the crystal structure of M22, a human thyroid-stimulating autoantibody (TSAb) bound to the TSH receptor (TSHR) leucine-rich repeat domain (LRD), the mechanism by which TSAs activate the TSHR and cause Graves' disease remains unknown. A nonstimulatory murine monoclonal ant...

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Bibliographische Detailangaben
Hauptverfasser: Hamidi, Sepehr, Chen, Chun-Rong, Murali, Ramachandran, McLachlan, Sandra M., Rapoport, Basil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2013
Schlagworte:
Thyroid-TRH-TSH
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529376/
https://ncbi.nlm.nih.gov/pubmed/23183178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1822
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