Identification of Key Amino Acid Residues in a Thyrotropin Receptor Monoclonal Antibody Epitope Provides Insight into Its Inverse Agonist and Antagonist Properties

by Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil
Published 2008

A Monoclonal Antibody with Thyrotropin (TSH) Receptor Inverse Agonist and TSH Antagonist Activities Binds to the Receptor Hinge Region as Well as to the Leucine-Rich Domain

by Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil
Published 2009

Thyrotropin (TSH) Receptor Residue E251 in the Extracellular Leucine-Rich Repeat Domain Is Critical for Linking TSH Binding to Receptor Activation

by Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil
Published 2010

Evidence That the Thyroid-stimulating Hormone (TSH) Receptor Transmembrane Domain Influences Kinetics of TSH Binding to the Receptor Ectodomain

by Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil
Published 2011

The Thyrotropin Receptor Hinge Region Is Not Simply a Scaffold for the Leucine-Rich Domain but Contributes to Ligand Binding and Signal Transduction

by Mizutori, Yumiko, Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil
Published 2008

Insight into Thyroid-Stimulating Autoantibody Interaction with the Thyrotropin Receptor N-Terminus Based on Mutagenesis and Re-Evaluation of Ambiguity in This Region of the Recepto...

by Hamidi, Sepehr, Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil
Published 2011

A homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, α cell hyperplasia, and islet cell tumor

by Zhou, Cuiqi, Dhall, Deepti, Nissen, Nicholas N., Chen, Chun-Rong, Yu, Run
Published 2009

An Attempt to Induce “Graves' Disease of the Gonads” by Immunizing Mice with the Luteinizing Hormone Receptor Provides Insight into Breaking Tolerance to Self-Antigens

by Chen, Chun-Rong, Aliesky, Holly A., Rapoport, Basil, McLachlan, Sandra M.
Published 2011

Novel Information on the Epitope of an Inverse Agonist Monoclonal Antibody Provides Insight into the Structure of the TSH Receptor

by Chen, Chun-Rong, Salazar, Larry M., McLachlan, Sandra M., Rapoport, Basil
Published 2012

Role of Self-Tolerance and Chronic Stimulation in the Long-Term Persistence of Adenovirus-Induced Thyrotropin Receptor Antibodies in Wild-Type and Transgenic Mice

by McLachlan, Sandra M., Aliesky, Holly A., Chen, Chun-Rong, Rapoport, Basil
Published 2012

The Thyrotropin Receptor Hinge Region as a Surrogate Ligand: Identification of Loci Contributing to the Coupling of Thyrotropin Binding and Receptor Activation

by Chen, Chun-Rong, Salazar, Larry M., McLachlan, Sandra M., Rapoport, Basil
Published 2012

IMMUNOGLOBULIN HEAVY CHAIN VARIABLE REGION GENES CONTRIBUTE TO THE INDUCTION OF THYROID STIMULATING ANTIBODIES IN RECOMBINANT INBRED MICE

by Rapoport, Basil, Williams, Robert W., Chen, Chun-Rong, McLachlan, Sandra M.
Published 2010

Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease

by Rapoport, Basil, Aliesky, Holly A., Chen, Chun-Rong, McLachlan, Sandra M.
Published in J Clin Endocrinol Metab (2015)

Deleting the Redundant TSH Receptor C-Peptide Region Permits Generation of the Conformationally Intact Extracellular Domain by Insect Cells

by Chen, Chun-Rong, Salazar, Larry M., McLachlan, Sandra M., Rapoport, Basil
Published in Endocrinology (2015)

Evidence that Shed Thyrotropin Receptor A Subunits Drive Affinity Maturation of Autoantibodies Causing Graves’ Disease

by Mizutori, Yumiko, Chen, Chun-Rong, Latrofa, Francesco, McLachlan, Sandra M., Rapoport, Basil
Published 2009

Variable Suppression of Serum Thyroxine in Female Mice of Different Inbred Strains by Triiodothyronine Administered in Drinking Water

by Hamidi, Sepehr, Aliesky, Holly, Chen, Chun-Rong, Rapoport, Basil, McLachlan, Sandra M.
Published 2010

Probing Structural Variability at the N Terminus of the TSH Receptor with a Murine Monoclonal Antibody That Distinguishes between Two Receptor Conformational Forms

by Hamidi, Sepehr, Chen, Chun-Rong, Murali, Ramachandran, McLachlan, Sandra M., Rapoport, Basil
Published 2013

Evidence that factors other than particular thyrotropin receptor T cell epitopes contribute to the development of hyperthyroidism in murine Graves' disease

by PICHURIN, P N, CHEN, CHUN-RONG, NAGAYAMA, Y, PICHURINA, O, RAPOPORT, B, MCLACHLAN, S M
Published 2004

Relationship between Thyrotropin Receptor Hinge Region Proteolytic Posttranslational Modification and Receptor Physiological Function

by Hamidi, Sepehr, Chen, Chun-Rong, Mizutori-Sasai, Yumiko, McLachlan, Sandra M., Rapoport, Basil
Published 2011

Structure of Co-2 × 2 nanoislands grown on Ag/Ge(111)-√3 × √3 surface studied by scanning tunneling microscopy

by Huang, Xiao-Lan, Lin, Chun-Liang, Tomaszewska, Agnieszka, Chen, Chun-Rong, Fu, Tsu-Yi
Published 2012