A Monoclonal Antibody with Thyrotropin (TSH) Receptor Inverse Agonist and TSH Antagonist Activities Binds to the Receptor Hinge Region as Well as to the Leucine-Rich Domain

Eitemau Tebyg

• Thyrotropin (TSH) Receptor Residue E251 in the Extracellular Leucine-Rich Repeat Domain Is Critical for Linking TSH Binding to Receptor Activation
  gan: Chen, Chun-Rong, et al.
  Cyhoeddwyd: (2010)
• Identification of Key Amino Acid Residues in a Thyrotropin Receptor Monoclonal Antibody Epitope Provides Insight into Its Inverse Agonist and Antagonist Properties
  gan: Chen, Chun-Rong, et al.
  Cyhoeddwyd: (2008)
• The Thyrotropin Receptor Hinge Region Is Not Simply a Scaffold for the Leucine-Rich Domain but Contributes to Ligand Binding and Signal Transduction
  gan: Mizutori, Yumiko, et al.
  Cyhoeddwyd: (2008)
• Novel Information on the Epitope of an Inverse Agonist Monoclonal Antibody Provides Insight into the Structure of the TSH Receptor
  gan: Chen, Chun-Rong, et al.
  Cyhoeddwyd: (2012)
• Structure of a Thyrotropin Receptor Monoclonal Antibody Variable Region Provides Insight into Potential Mechanisms for its Inverse Agonist Activity
  gan: Chen, Chun-Rong, et al.
  Cyhoeddwyd: (2018)