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Identification of Key Amino Acid Residues in a Thyrotropin Receptor Monoclonal Antibody Epitope Provides Insight into Its Inverse Agonist and Antagonist Properties

CS-17 is a murine monoclonal antibody to the human TSH receptor (TSHR) with both inverse agonist and antagonist properties. Thus, in the absence of ligand, CS-17 reduces constitutive TSHR cAMP generation and also competes for TSH binding to the receptor. The present data indicate that for both of th...

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Sonraí Bibleagrafaíochta
Main Authors: Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Endocrine Society 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453077/
https://ncbi.nlm.nih.gov/pubmed/18388191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0207
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