Structure of a Thyrotropin Receptor Monoclonal Antibody Variable Region Provides Insight into Potential Mechanisms for its Inverse Agonist Activity

Background: The high constitutive, or ligand-independent, activity of the thyrotropin receptor (TSHR) is of clinical importance in some thyroid conditions, particularly well-differentiated thyroid carcinoma remnants following incomplete ablative therapy (surgery and radioiodine). Under these conditi...

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Detalhes bibliográficos
Publicado no:Thyroid
Main Authors: Chen, Chun-Rong, McLachlan, Sandra M., Hubbard, Paul A., McNally, Randall, Murali, Ramachandran, Rapoport, Basil
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2018
Assuntos:
Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043401/
https://ncbi.nlm.nih.gov/pubmed/29845889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2018.0176
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