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Thyrotropin (TSH) Receptor Residue E251 in the Extracellular Leucine-Rich Repeat Domain Is Critical for Linking TSH Binding to Receptor Activation

The TSH receptor (TSHR) ectodomain comprises a tubular leucine-rich repeat domain (LRD) and a hinge [or signaling specificity domain (SSD)]. TSH binds to both the LRD and SSD, leading to signal transduction by the transmembrane domain. The SSD structure and spatial orientation to the other component...

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Bibliografiske detaljer
Main Authors: Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851189/
https://ncbi.nlm.nih.gov/pubmed/20181794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1430
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