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Evidence That the Thyroid-stimulating Hormone (TSH) Receptor Transmembrane Domain Influences Kinetics of TSH Binding to the Receptor Ectodomain

Thyroid-stimulating hormone (TSH)-induced reduction in ligand binding affinity (negative cooperativity) requires TSH receptor (TSHR) homodimerization, the latter involving primarily the transmembrane domain (TMD) but with the extracellular domain (ECD) also contributing to this association. To test...

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Bibliographic Details
Main Authors: Chen, Chun-Rong, McLachlan, Sandra M., Rapoport, Basil
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057818/
https://ncbi.nlm.nih.gov/pubmed/21190937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211003
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