Deleting the Redundant TSH Receptor C-Peptide Region Permits Generation of the Conformationally Intact Extracellular Domain by Insect Cells

The TSH receptor (TSHR) extracellular domain (ECD) comprises a N-terminal leucine-rich repeat domain and an hinge region (HR), the latter contributing to ligand binding and critical for receptor activation. The crystal structure of the leucine-rich repeat domain component has been solved, but previo...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Chen, Chun-Rong, Salazar, Larry M., McLachlan, Sandra M., Rapoport, Basil
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Technical Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475722/
https://ncbi.nlm.nih.gov/pubmed/25860033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1154
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