Novel interactions of fluorinated nucleotide derivatives targeting orotidine-5′-monophosphate decarboxylase

Fluorinated nucleosides and nucleotides are of considerable interest to medicinal chemists due to their antiviral, anticancer, and other biological activities. However, their direct interactions at target binding sites are not well understood. A new class of 2′-deoxy-2′-fluoro-C6-substituted uridine...

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Main Authors: Lewis, Melissa, Avina, Maria Elena Meza, Wei, Lianhu, Crandall, Ian E., Bello, Angelica Mara, Poduch, Ewa, Liu, Yan, Paige, Christopher J., Kain, Kevin C., Pai, Emil F., Kotra, Lakshmi P.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083246/
https://ncbi.nlm.nih.gov/pubmed/21417464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101642g
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