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Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase
Orotidine 5'-monophosphate decarboxylase (ODCase) accelerates the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) by 17 orders of magnitude. Eight new crystal structures with ligand analogues combined with computational analyses of the enzyme’s sh...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3949427/ https://ncbi.nlm.nih.gov/pubmed/24151964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja408197k |
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