Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase

Orotidine 5'-monophosphate decarboxylase (ODCase) accelerates the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) by 17 orders of magnitude. Eight new crystal structures with ligand analogues combined with computational analyses of the enzyme’s sh...

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Main Authors: Fujihashi, Masahiro, Ishida, Toyokazu, Kuroda, Shingo, Kotra, Lakshmi P., Pai, Emil F., Miki, Kunio
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949427/
https://ncbi.nlm.nih.gov/pubmed/24151964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja408197k
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