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Structural Characterization of the Molecular Events during a Slow Substrate-Product Transition in Orotidine 5′-Monophosphate Decarboxylase
Crystal structures of substrate/product complexes of Methanobacterium thermoautotrophicum orotidine-5′-monophosphate decarboxylase, obtained at various steps in its catalysis of the unusual transformation of 6-CN-UMP into barbituric acid ribosyl monophosphate (BMP), show that the cyano substituent o...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3125131/ https://ncbi.nlm.nih.gov/pubmed/19236876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.02.037 |
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