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Structural Characterization of the Molecular Events during a Slow Substrate-Product Transition in Orotidine 5′-Monophosphate Decarboxylase

Crystal structures of substrate/product complexes of Methanobacterium thermoautotrophicum orotidine-5′-monophosphate decarboxylase, obtained at various steps in its catalysis of the unusual transformation of 6-CN-UMP into barbituric acid ribosyl monophosphate (BMP), show that the cyano substituent o...

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Main Authors: Fujihashi, Masahiro, Bello, Angelica M., Kotra, Lakshmi P., Pai, Emil F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125131/
https://ncbi.nlm.nih.gov/pubmed/19236876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.02.037
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